Outer membrane porins contribute to antimicrobial resistance in gram-negative bacteria

G Zhou, Q Wang, Y Wang, X Wen, H Peng, R Peng… - Microorganisms, 2023 - mdpi.com
Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

Integrons as the potential targets for combating multidrug resistance in Enterobacteriaceae using CRISPR- Cas9 technique

VP Shetty, SD Akshay, P Rai… - Journal of applied …, 2023 - academic.oup.com
The emergence of multi-drug resistance (MDR) to pan-drug resistance (PDR) in
Enterobacteriaceae has made treatment extremely challenging. Genetic mutations and …

Multi-omics reveals the increased biofilm formation of Salmonella Typhimurium M3 by the induction of tetracycline at sub-inhibitory concentrations

L Yuan, L Fan, H Dai, G He, X Zheng, S Rao… - Science of the Total …, 2023 - Elsevier
Exposure to sub-inhibitory concentrations (sub-MICs) of antibiotics could induce the biofilm
formation of microorganisms, but its underlying mechanisms still remain elusive. In the …

Antibiotic resistance mechanism and diagnosis of common foodborne pathogens based on genotypic and phenotypic biomarkers

X Liao, R Deng, K Warriner… - Comprehensive Reviews in …, 2023 - Wiley Online Library
The emergence of antibiotic‐resistant bacteria due to the overuse or inappropriate use of
antibiotics has become a significant public health concern. The agri‐food chain, which …

Outer Membrane Proteins and Efflux Pumps Mediated Multi-Drug Resistance in Salmonella: Rising Threat to Antimicrobial Therapy

SD Akshay, VK Deekshit, J Mohan Raj… - ACS Infectious …, 2023 - ACS Publications
Despite colossal achievements in antibiotic therapy in recent decades, drug-resistant
pathogens have remained a leading cause of death and economic loss globally. One such …

Differential expression of outer membrane proteins and quinolone resistance determining region mutations can lead to ciprofloxacin resistance in Salmonella Typhi

SD Akshay, S Nayak, VK Deekshit, A Rohit… - Archives of …, 2023 - Springer
Multi-drug resistance in Salmonella Typhi remains a public health concern globally. This
study aimed to investigate the function of quinolone resistance determining region (QRDR) …

Analysis of mcr family of colistin resistance genes in Gram-negative isolates from a tertiary care hospital in India

D Irusan, SD Akshay, VP Shetty… - Journal of Applied …, 2024 - academic.oup.com
Aim Colistin serves as the drug of last resort for combating numerous multidrug-resistant
(MDR) Gram-negative infections. Its efficacy is hampered by the prevalent issue of colistin …

Polymerase chain reaction-based typing methods and protein profiling analysis of Acinetobacter baumannii isolated from environmental and clinical sources from …

S Nayak, DA Aanice, D Andria, A Pai… - Canadian Journal of …, 2023 - cdnsciencepub.com
Acinetobacter baumannii is an opportunistic pathogen known for causing hospital-acquired
infections. The natural habitat includes soil, water, sewage, and drains, but it is also detected …

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

AR Chowdhury, D Mukherjee… - Molecular …, 2024 - Wiley Online Library
Salmonella Typhi, the invasive serovar of S. enterica subspecies enterica, causes typhoid
fever in healthy human hosts. The emergence of antibiotic‐resistant strains has consistently …

ompX contribute to biofilm formation, osmotic response and swimming motility in Citrobacter werkmanii

G Zhou, Y Wang, H Peng, S Li, T Sun, C Li, Q Shi, X Xie - Gene, 2023 - Elsevier
Citrobacter werkmanii, an aerobe and mesophilic Proteobacterium, is universal in industrial
putrefaction, coastal water, and human blood. Our previous studies have discovered that …