Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-
order levels, an organization that guides our current understanding of their biological …

The granzymes are cell death–inducing enzymes, stored in the cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis …

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme
pathway as a major mechanism to kill pathogen-containing cells and tumor cells …

Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

Cytotoxicity and Wound Healing Evidence for the Role of Elastase in ARDS in Humans
Animal Models of Lung Injury and Leukocyte Elastase Studies of Protease Inhibitors and …

Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules.
GzmA activates a novel programed cell death pathway that begins in the mitochondrion …

Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to
kill virus-infected and tumor cells. Major recent advances in our understanding of granzyme …

Granzymes (Grs) were discovered just over a quarter century ago. They are produced by
cytotoxic T cells and natural killer cells and are released upon interaction with target cells …