The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …

Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …

Glucocorticoids (GCs) are used in treating viral infections, acute spinal cord injury,
autoimmune diseases, and shock. Several patients develop GC‐induced osteonecrosis of …

Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Abstract Background and Purpose Endocannabinoid (eCB) signalling gates many aspects
of the stress response, including the hypothalamic–pituitary–adrenal (HPA) axis. The HPA …

Neurological and neurodegenerative diseases are debilitating conditions, and frequently
lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the …

Peripheral inflammatory conditions, including those localized to the gastrointestinal tract, are
highly comorbid with psychiatric disorders such as anxiety and depression. These …

As social beings, animals and humans alike make real life decisions that are often
influenced by other members. Most current research has focused on the influence of same …

CB1 receptor antagonists disrupt operant responding for food and drug reinforcers, and cue-
induced reinstatement of cocaine and heroin seeking. Conversely, enhancing …

Abstract Background 4− 20% of people report using cannabis during pregnancy, thereby it is
essential to assess the associated risks. There is some evidence that prenatal cannabis …