Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of
advantages over previous cardiac models, however, questions of their immaturity complicate …

HL-1 cells are currently the only cardiomyocyte cell line available that continuously divides
and spontaneously contracts while maintaining a differentiated cardiac phenotype …

We demonstrated a bioelectronic heart-on-a-chip model for studying the effects of acute
hypoxia on cardiac function. A microfluidic channel enabled rapid modulation of medium …

Action potentials have a central role in the nervous system and in many cellular processes,
notably those involving ion channels. The accurate measurement of action potentials …

Multi-electrode arrays (MEAs) have become a key element in the study of cellular
phenomena in vitro. Common modern MEAs are still based on costly microfabrication …

Biochemical studies have established the presence of a NO pathway in the heart, including
sources of NO and various effectors. Several cardiac ion channels have been shown to be …

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in
the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity …

The transient receptor potential melastatin 4 (TRPM4) channel contributes extensively to
cardiac electrical activity, especially cardiomyocyte action potential formation. Mechanical …

Mitochondrial Ca2+ is known to change dynamically, regulating mitochondrial as well as
cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the …

Protein misfolding and aggregation are associated with a number of human degenerative
diseases. In spite of the enormous research efforts to develop effective strategies aimed at …