Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Antibiotics belongs to a class of pharmaceutical compounds widely used due to their
effectiveness against bacterial infections. However, if consumed or inappropriately disposed …

Structural and biological evaluation of newly designed and synthesized diazepanone
derivatives (3a-c) with modified functionalities is reported in this paper, as liponucleoside …

Nucleoside derivatives, in particular those featuring uridine, are familiar components of the
nucleoside family of bioactive natural products. The structural complexity and biological …

Liposidomycin is a uridyl liponucleoside antibiotic isolated from Streptomyces griseosporeus
RK-1061. It was discovered by Isono in 1985, who had previously isolated and developed a …

Antibiotic resistance poses an increasing threat to global health, and it is urgent to reverse
the present trend by accelerating development of new natural product derived drugs …

In the present study, we generated a ligand-based scaffold model from a known bioactive
datasets of mur enzymes of other species to identify multi-targeting inhibitors as …

A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to
a full stereochemistry assignment of the structurally unique nucleoside antibiotic A‐94964 …

New inhibitors of the bacterial transferase MraY from Aquifex aeolicus (MraYAA), based on
the aminoribosyl uridine central core of known natural MraY inhibitors, have been designed …