Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Mitochondria are dynamic organelles of endosymbiotic origin that are essential components
of eukaryal cells. They contain their own genetic machinery, have multicopy genomes and …

The human mitochondrial genome encodes thirteen core subunits of the oxidative
phosphorylation system, and defects in mitochondrial gene expression lead to severe …

Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a
long-standing goal and would be of great relevance for disease modeling and for clinical …

Primary mitochondrial diseases represent some of the most common and severe inherited
metabolic disorders, affecting~ 1 in 4,300 live births. The clinical and molecular diversity …

Mitochondria are important organelles that harbor their own genomes encoding a key set of
proteins that ensure respiration and provide the eukaryotic cell with energy. Recent …

Mitochondrial diseases (MDs) are a group of severe genetic disorders caused by mutations
in the nuclear or mitochondrial genome encoding proteins involved in the oxidative …

The mitochondrial ATP synthase (F1–F0 complex) of Saccharomces cerevisiae is a
composite of different structural and functional units that jointly couple ATP synthesis and …

Respiratory chain complexes in mitochondria are assembled from subunits derived from two
genetic systems. For example, the bc1 complex consists of nine nuclear encoded subunits …

Mitochondria contain their own genetic system to express a small number of hydrophobic
polypeptides, including cytochrome b, an essential subunit of the bc1 complex of the …