At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable
tool in regenerative medicine. In response to differentiation cues, they can activate markedly …

The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED,
RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on …

Abstract DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …

Intellectual disability (ID) is a neurodevelopmental condition that affects~ 1% of the world
population. In total 5− 10% of ID cases are due to variants in genes located on the X …

SAP30 is a core subunit of the transcriptional corepressor SIN3 complex, but little is known
about its role in gene regulation and human cancer. Here, we show that SAP30 was a …

Sin3a is a core component of histone-deacetylation-activity-associated transcriptional
repressor complex, playing important roles in early embryo development. Here, we reported …

Histone acetylation is a dynamic modification regulated by the opposing actions of histone
acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails …

O-GlcNAc transferase (OGT) is the sole enzyme responsible for the post-translational
modification O-GlcNAc on thousands of target nucleocytoplasmic proteins. To date, nine …

Lysine specific demethylase 1 (LSD1) regulates gene expression as part of the CoREST
complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1) …