The role of early growth response 1 (EGR1) in brain plasticity and neuropsychiatric disorders
F Duclot, M Kabbaj - Frontiers in behavioral neuroscience, 2017 - frontiersin.org
It is now clearly established that complex interactions between genes and environment are
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
AY Lai, PA Wade - Nature Reviews Cancer, 2011 - nature.com
The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …
regulates gene expression at the level of chromatin. The NuRD complex has been identified …
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing
A 44-year old woman with recurrent solitary fibrous tumor (SFT)/hemangiopericytoma was
enrolled in a clinical sequencing program including whole-exome and transcriptome …
enrolled in a clinical sequencing program including whole-exome and transcriptome …
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
M Trizzino, A Zucco, S Deliard, F Wang, E Barbieri… - Science …, 2021 - science.org
Monocytes and monocyte-derived macrophages originate through a multistep differentiation
process. First, hematopoietic stem cells generate lineage-restricted progenitors that …
process. First, hematopoietic stem cells generate lineage-restricted progenitors that …
Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ
YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators
downstream of the Hippo tumor-suppressor pathway. However, whether YAP and/or TAZ …
downstream of the Hippo tumor-suppressor pathway. However, whether YAP and/or TAZ …
Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene …
A Mohajeri, J Tayebwa, A Collin… - Genes …, 2013 - Wiley Online Library
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm displaying variable morphologic
and clinical features. To identify pathogenetically important genetic rearrangements, 44 …
and clinical features. To identify pathogenetically important genetic rearrangements, 44 …
Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …
Objective To discover common genetic variants contributing to the risk of PCa in men of …
[HTML][HTML] Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and …
S Barthelmeß, H Geddert, C Boltze… - The American journal of …, 2014 - Elsevier
Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6,
located at chromosomal region 12q13, have been recently identified to be presumable …
located at chromosomal region 12q13, have been recently identified to be presumable …
Significance of heparanase in cancer and inflammation
Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …
Schwann cell development and myelination
Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …