The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

Abstract N6‐methyladenosine (m6A) and long noncoding RNAs (lncRNAs) are both crucial
regulators in non‐small‐cell lung cancer (NSCLC) tumorigenesis. However, the pathological …

The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Abstract N 6-methyladenosine (m 6 A) is the most abundant and diverse epigenetic
modification of mRNAs in eukaryotes, and it regulates biological metabolism, cell …

RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

Abstract Background N4-acetylcytidine (ac4C) as a significant RNA modification has been
reported to maintain the stability of mRNA and to regulate the translation process. However …

Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …

Abstract Abnormal 5-methylcytosine (m5C) methylation has been proved to be closely
related to gastric carcinogenesis, progression, and prognosis. Dysregulated long noncoding …