The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

With advances in neonatal care, preterm neonates are surviving with an evolving
constellation of motor and cognitive disabilities that appear to be related to widespread …

Cerebral palsy (CP) is a chronic childhood disorder with no effective cure.
Neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the …

The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker
in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from …

Abnormal development of the brain during fetal life is now thought to contribute to the
aetiology of many neurological disorders that manifest throughout life. Many factors are …

A compromised intrauterine environment that delivers low levels of oxygen and/or nutrients,
or is infected or inflammatory, can result in fetal brain injury, abnormal brain development …

Injury to the preterm brain has a particular predilection for cerebral white matter. White
matter injury (WMI) is the most common cause of brain injury in preterm infants and a major …

Neuroinflammation, mediated by activated microglia and astrocytes, plays a key role in the
pathogenesis of many neurological disorders. Systemically-administered dendrimers target …

Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental
programming'and today's discipline of the Developmental Origins of Health and Disease …