Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Diagnostics to accurately detect disease and monitor therapeutic response are essential for
effective clinical management. Bioengineering, chemical biology, molecular biology, and …

The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug
discovery. This protease activates the Spike protein of severe acute respiratory syndrome …

Skin provides the first defense against pathogenic micro-organisms and is also colonized by
a diverse microbiota. Phylogenetic analysis of whole skin microbiome at different skin sites …

The biology of human granzymes remains enigmatic in part due to our inability to probe their
functions outside of in vitro assays or animal models with divergent granzyme species. We …

All living organisms depend on tightly regulated cellular networks to control biological
functions. Proteolysis is an important irreversible post-translational modification that …

Single-copy loss-of-function mutations in the progranulin gene (PGRN) underlie the
neurodegenerative disease frontotemporal lobar degeneration, while homozygous loss-of …

Proteases are enzymes that cleave proteins and are crucial to physiological processes such
as digestion, blood clotting, and wound healing. Unregulated protease activity is a …

Neuropeptides mediate cell–cell signaling in the nervous and endocrine systems. The
neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within …

Enzymes that modify the proteome, referred to as post‐translational modifying (PTM)
enzymes, are central regulators of cellular signaling. Determining the substrate specificity of …