More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Disruption of the MDM2-p53 protein-protein interaction by small-molecule inhibitors has
been highly pursued by many academic laboratories and pharmaceutical companies as a …

Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Abstract NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating
enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F …

Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …

Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …

Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a
ubiquitin-like protein that conjugates to and regulates the biological function of its substrates …