Fibroblast and myofibroblast activation in normal tissue repair and fibrosis

FS Younesi, AE Miller, TH Barker, FMV Rossi… - … Reviews Molecular Cell …, 2024 - nature.com
The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

M Ezzo, B Hinz - Pharmacology & therapeutics, 2023 - Elsevier
The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

[HTML][HTML] GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

Y Okamoto, K Kitakaze, Y Takenouchi, R Matsui… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Fibrosis is characterized by excessive deposition of extracellular matrix proteins, particularly
collagen, caused by myofibroblasts in response to chronic inflammation. Although G protein …

Cellular reprogramming of fibroblasts in heart regeneration

C Chi, K Song - Journal of Molecular and Cellular Cardiology, 2023 - Elsevier
Myocardial infarction causes the loss of cardiomyocytes and the formation of cardiac fibrosis
due to the activation of cardiac fibroblasts, leading to cardiac dysfunction and heart failure …

[HTML][HTML] Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway

J He, B Fang, S Shan, Q Li - Journal of Dermatological Science, 2024 - Elsevier
Background Myofibroblasts contribute to the excessive production, remodeling and cross-
linking of the extracellular matrix that characterizes the progression of skin fibrosis. An …

The role of RGS5 in cardiac pericytes

A Tamiato - 2023 - publikationen.ub.uni-frankfurt.de
Pericytes are capillary-associated mural cells involved in the maintenance and the stability
of the vascular network. This thesis aims to investigate the role of pericytes in the heart in the …

[引用][C] 基于β 肾上腺素能受体信号通路防治心力衰竭的中西医研究进展

史天云, 鲁成, 刘永明 - 中国医药导报 - yiyaodaobao.com.cn
心力衰竭是各种原因所致心脏疾病的终末阶段, B 肾上腺素能受体信号通路异常是心力衰竭发生,
发展的重要病理生理机制之¢, 三种3 肾上腺素能受体介导的信号通路及受体数量异常在心力 …