Young myeloma patients: A systematic review of manifestations and outcomes

M Tanguay, C Dagenais, R LeBlanc, I Ahmad… - Current …, 2023 - mdpi.com
Multiple myeloma usually affects older adults. However, younger patients constitute a
significant subset as approximately 10% of cases occur in subjects younger than 50 years …

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

A Vdovin, T Jelinek, D Zihala, T Sevcikova… - Nature …, 2022 - nature.com
Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with
multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM …

Complete variable domain sequences of monoclonal antibody light chains identified from untargeted RNA sequencing data

A Nau, Y Shen, V Sanchorawala, T Prokaeva… - Frontiers in …, 2023 - frontiersin.org
Introduction Monoclonal antibody light chain proteins secreted by clonal plasma cells cause
tissue damage due to amyloid deposition and other mechanisms. The unique protein …

Light chain myeloma and detection of free light chains in serum and urine of dogs and cats

RA Harris, M Miller, D Donaghy… - Journal of veterinary …, 2021 - Wiley Online Library
Background Detection of free light chains (fLC) in animals relies on protein electrophoresis
or the Bence‐Jones protein test on urine. Objective To describe the detection of both serum …

Outcomes of ixazomib/lenalidomide/dexamethasone for multiple myeloma: A multicenter retrospective analysis

T Takakuwa, R Yamamura, K Ohta… - European Journal of …, 2021 - Wiley Online Library
Objectives This study aimed to investigate real‐world data of ixazomib plus lenalidomide
and dexamethasone (IRd) therapy for patients with relapsed and refractory multiple …

Multiple myeloma presenting in patients younger than 50 years of age: a single institution experience

A Duek, L Trakhtenbrot, A Avigdor, A Nagler… - Acta …, 2021 - karger.com
Introduction: Multiple myeloma (MM) is uncommon in persons younger than 50 years of age.
The presenting features in this age group are unclear. Methods: We analyzed a cohort of …

Machine Learning Approach for Rapid, Accurate Point-of-Care Prediction of M-Spike Values in Multiple Myeloma

E Malek, GM Wang, C Tatsuoka, J Cullen… - JCO Clinical Cancer …, 2023 - ascopubs.org
PURPOSE The gold standard for monitoring response status in patients with multiple
myeloma (MM) is serum and urine protein electrophoresis which quantify M-spike proteins; …

The significance of autologous hematopoietic stem cell transplantation on immunoglobulin reconstitution and prognosis in elderly patients with multiple myeloma

A Lei, X Liao, P Zhu, M Xiong - Hematology, 2023 - Taylor & Francis
Objectives Autologous hematopoietic stem cell transplantation (ASCT) is a crucial method
used in patients with multiple myeloma (MM). This study aims to evaluate the role of ASCT in …

Machine learning evaluation for identification of M-proteins in human serum

A Sopasakis, M Nilsson, M Askenmo, F Nyholm… - Plos one, 2024 - journals.plos.org
Serum electrophoresis (SPEP) is a method used to analyze the distribution of the most
important proteins in the blood. The major clinical question is the presence of monoclonal …

[HTML][HTML] Monoclonal Light Chains with alpha 2 mobility on Serum Protein Electrophoresis

S Danalakshmi - EJIFCC, 2023 - ncbi.nlm.nih.gov
Multiple myeloma (MM) is a neoplasm characterized by malignant proliferation of plasma
cells that produce excessive quantities of a single type of immunoglobulin (Ig) called as …