Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Early-Life Origins of Chronic Obstructive Pulmonary Disease | New England Journal of Medicine
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Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …

There is poor agreement on definitions of different phenotypes of preschool wheezing
disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to …

Airway remodeling encompasses the structural alterations in asthmatic compared with
normal airways. Airway remodeling in asthmatic patients involves a wide array of …

Background Pathological features of the airway in young children with severe recurrent
wheeze suggest an association between bacterial colonization and the initiating events of …

While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Introduction There is epidemiological evidence to suggest that events in childhood influence
lung growth and constitute a significant risk for adult COPD. The aim of the study is to …