Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its
negative impact and thus results in anxiety. Here, we focus the broad literature on the …

Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …

Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–
60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case …

Key Clinical Points Generalized Anxiety Disorder Generalized anxiety disorder is
characterized by persistent anxiety and uncontrollable worry that occurs consistently for at …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Anxiety disorders are among the most prevalent mental disorders, but the subcategory of
specific phobias has not been well studied. Phobias involve both fear and avoidance. For …

Objective: Diagnosis is a cornerstone of clinical practice for mental health care providers, yet
traditional diagnostic systems have well-known shortcomings, including inadequate …

This review serves as a systematic guide to the genetics of generalized anxiety disorder
(GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry …

Childhood and adolescence is the core risk phase for the development of symptoms and
syndromes of anxiety that may range from transient mild symptoms to full-blown anxiety …