Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Methadone is widely used for the treatment of opioid dependence. Although in most
countries the drug is administered as a racemic mixture of (R)-and (S)-methadone,(R) …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Opioid substitution treatment for dependence may alter sensitivity to pain. Previous studies
on pain sensitivity in methadone maintenance patients have yielded contradictory results …

About 56% of the drugs currently in use are chiral compounds, and 88% of these chiral
synthetic drugs are used therapeutically as racemates. Only a few of these drugs qualify for …

Background Metabolism and clearance of racemic methadone are stereoselective and
highly variable, yet the mechanism remains largely unknown. Initial in vitro studies attributed …

Background and Purpose Opioids may inhibit the 5‐HT transporter (SERT) and the
noradrenaline transporter (NET). NET inhibition may contribute to analgesia, and SERT …

Most women using heroin are of reproductive age with major risks for their infants. We
review clinical and experimental data on fetal, neonatal and postnatal complications …

We have previously shown that methadone maintenance patients are hyperalgesic. Very
little is known about the antinociceptive effects of additional opioids in these patients. This …

Aim Conducting PK studies in pregnant women is challenging. Therefore, we asked if a
physiologically‐based pharmacokinetic (PBPK) model could be used to predict the …