Regulatory T cell (Treg) suppression of conventional T cells is a central mechanism that
ensures immune system homeostasis. The exact time point of Treg emergence is still …

Although the liver of the lamprey, a group of cyclostomes that diverged the earliest among
vertebrates, has abundant bile ducts in the larval stage, which degenerate during …

Comparative genomic analyses have enormous potential for identifying key genes central to
human health phenotypes, including those that promote cancers. In particular, the …

Lamprey underwent biliary atresia (BA) at its metamorphosis stage. In contrast to patients
with BA who develop progressive disease, lamprey can grow and develop normally …

Aim Excess cholesterol deposition in lysosomes may result in lysosomal stress and
dysfunction. Here, we focus on the role of lysosome membrane protein 2 (LIMP2) in relieving …

七鳃鳗是现存的无颌类脊椎动物代表之一, 距今已有5 亿多年的历史, 素有“活化石” 之称.
古老的七鳃鳗凭借独特的功能特征和进化地位吸引了众多学者的注意: 在免疫系统方面 …

胆道闭锁(biliary atresia, BA) 是一种罕见的婴幼儿肝胆疾病, 其特征是纤维硬化性胆管病变,
导致肝外胆管和肝内胆管阻塞或闭塞, 胆汁不能向肠道排泄, 胆汁酸对肝实质细胞造成严重损伤 …

Background: Biliary Atresia (BA) is a devastating pediatric cholangiopathy affecting the bile
ducts of the liver. Current research has found a variety of causes for BA, with inflammation …

Circular RNAs (circRNAs) serve an essential role in the occurrence and development of
cholangiocarcinoma, but the expression and function of circRNA in biliary atresia (BA) is not …