The formulation of nanomedicines for treating tuberculosis

A Costa, M Pinheiro, J Magalhães, R Ribeiro… - Advanced drug delivery …, 2016 - Elsevier
Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide,
alongside the human immunodeficiency virus (HIV) infection. The current treatment is …

Dry powder inhalable formulations for anti-tubercular therapy

T Parumasivam, RYK Chang, S Abdelghany… - Advanced drug delivery …, 2016 - Elsevier
Tuberculosis (TB) is an intracellular infectious disease caused by the airborne bacterium,
Mycobacterium tuberculosis. Despite considerable research efforts, the treatment of TB …

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

A Schoubben, M Ricci, S Giovagnoli - Journal of Pharmaceutical …, 2019 - Springer
Background Polylactides (PLA) and poly lactide-co-glycolides (PLGA) undoubtedly are
among the major drivers in the pharmaceutical market. Their relevance in pharmaceutics …

Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine

I Sibum, P Hagedoorn, MPG Kluitman, M Kloezen… - Pharmaceutics, 2019 - mdpi.com
Tuberculosis is the leading cause of death from a single infectious pathogen worldwide.
Lately, the targeted delivery of antibiotics to the lungs via inhalation has received increasing …

High dose dry powder inhalers to overcome the challenges of tuberculosis treatment

MAM Momin, IG Tucker, SC Das - International journal of pharmaceutics, 2018 - Elsevier
Tuberculosis (TB) is a major global health burden. The emergence of the human
immunodeficiency virus (HIV) epidemic and drug resistance has complicated global TB …

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

D Thiyagarajan, B Huck, B Nothdurft, M Koch… - Drug delivery and …, 2021 - Springer
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging
because the aerodynamic properties of nanomaterials are sub-optimal for such purposes …

The influence of surface active l-leucine and 1, 2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) in the improvement of aerosolization of pyrazinamide and …

BB Eedara, B Rangnekar, C Doyle, A Cavallaro… - International journal of …, 2018 - Elsevier
Pharmacotherapy of tuberculosis is potentially more efficient when delivered by the inhaled
route than by the current oral and/or parenteral routes due to the higher concentration of …

Formulation techniques for high dose dry powders

AD Brunaugh, HDC Smyth - International journal of pharmaceutics, 2018 - Elsevier
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the
treatment of both local pulmonary conditions and systemic diseases. Though DPIs are …

Formulation and optimization of long acting dual niosomes using box-Behnken experimental design method for combinative delivery of ethionamide and D …

P Kulkarni, D Rawtani, T Barot - Colloids and Surfaces A: Physicochemical …, 2019 - Elsevier
The ability of niosomes to entrap both hydrophilic (D-Cycloserine) and lipophilic
(Ethionamide) drugs was utilized to make an effective formulation for combating drug …

Bedaquiline containing triple combination powder for inhalation to treat drug-resistant tuberculosis

B Rangnekar, MAM Momin, BB Eedara, S Sinha… - International journal of …, 2019 - Elsevier
Drug-resistant tuberculosis (DR-TB) is an emerging health problem, challenging the
effective control of global TB. Current treatment of DR-TB includes administration of multiple …