Obestatin is a 23‐amino acid C‐terminally amidated gastrointestinal peptide derived from
preproghrelin and which forms an α helix. Although obestatin has a short biological half‐life …

Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …

Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX
inhibits food intake and reduces body weight. In obese humans, SPX is the most down …

Obestatin was identified in 2005 by Zhang and colleagues as a ghrelin-associated peptide,
derived from posttranslational processing of the prepro-ghrelin gene. Initially, obestatin was …

背景: 肥胖抑制素在调节食物摄入与能量消耗方面具有重要作用, 但是肥胖抑制素与GPR39
受体在1 型与2 型糖尿病(T1DM 与T2DM) 中的作用目前尚未十分明确. 当前这项研究的目的是 …

The present study aimed to characterize the role of spexin (SPX) in maintaining glucose and
lipid homeostasis in vivo in rats with diet-induced obesity. The in vitro effect of spexin on …

Introduction Kisspeptin, which is encoded by the KISS1 gene and acts via GPR54, plays a
role in the regulation of reproductive functions. Expression of KISS1 and GRPR54 has been …

Ghrelin gene products—the peptides ghrelin, unacylated ghrelin, and obestatin—have
several actions on the immune system, opening new perspectives within …

It is well known that orexins are involved in the metabolism and endocrine function of rodent
adipocytes, but there are no data on other animal species, including pigs. Therefore, in this …

Ghrelin and obestatin are two “sibling proteins” encoded by the same preproghrelin gene
but possess an array of diverse and complex functions. While there are ample literature …