Thalassaemia is a diverse group of genetic disorders with a worldwide distribution affecting
globin chain synthesis. The pathogenesis of thalassaemia lies in the unbalanced globin …

Abstract β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red
blood cell transfusions and iron chelation therapy to prevent complications due to iron …

Introduction: Anemia in children is a major public health problem throughout the world. It is
often multifactorial, iron deficiency being the most frequent etiology. Consequences are …

This systematic literature review assessed the global prevalence and birth prevalence of
clinically significant forms of alpha‐and beta‐thalassemia. Embase, MEDLINE, and the …

Hemoglobinopathies are among the most common autosomal-recessive disorders
worldwide. A comprehensive next-generation sequencing (NGS) test would greatly facilitate …

Purpose β-Thalassemia is an inherited blood disorder characterized by reduced or no
production of adult hemoglobin. Systematic identification of the burden of β-thalassemia with …

Red blood cell (RBC) transfusions can be life‐sustaining in chronic inherited anaemias,
such as thalassaemia, and the indications for blood transfusions in patients with sickle cell …

The thalassemia syndromes are hemoglobin disorders that result from significantly reduced
or absent synthesis of either the α-or β-globin chains. The result is a chronic hemolytic …

Patients with sickle cell disease (SCD) and thalassemia experience several complications
across their lifespan that lead to impairment in different health-related quality of life (HRQOL) …

Mutations in human Krüppel-like factor 1 (KLF1) have recently been reported to be
responsible for increased fetal hemoglobin (HbF) and hemoglobin A2 (HbA2). Because …