Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Ischemic heart disease and heart failure: role of coronary ion channels

P Severino, A D'Amato, M Pucci, F Infusino… - International journal of …, 2020 - mdpi.com
Heart failure is a complex syndrome responsible for high rates of death and hospitalization.
Ischemic heart disease is one of the most frequent causes of heart failure and it is normally …

Calcium in the pathophysiology of atrial fibrillation and heart failure

NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Comorbidity of atrial fibrillation and heart failure

LH Ling, PM Kistler, JM Kalman, RJ Schilling… - Nature Reviews …, 2016 - nature.com
Atrial fibrillation (AF) and heart failure (HF) are evolving epidemics, together responsible for
substantial human suffering and health-care expenditure. Ageing, improved cardiovascular …

Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase

JY Youn, J Zhang, Y Zhang, H Chen, D Liu… - Journal of molecular and …, 2013 - Elsevier
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Patients with AF have up to
seven-fold higher risk of suffering from ischemic stroke. Better understanding of etiologies of …

Dynamics of atrial fibrillation mechanisms and comorbidities

J Heijman, D Linz, U Schotten - Annual review of physiology, 2021 - annualreviews.org
Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …

Profibrotic, electrical, and calcium-handling remodeling of the atria in heart failure patients with and without atrial fibrillation

CE Molina, IH Abu-Taha, Q Wang… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases that often
co-exist. Animal models have suggested complex AF-promoting atrial structural, electrical …

Arrhythmogenic remodeling in the failing heart

Z Husti, A Varró, I Baczkó - Cells, 2021 - mdpi.com
Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Role of oxidative stress in the genesis of ventricular arrhythmias

A Adameova, AK Shah, NS Dhalla - International Journal of Molecular …, 2020 - mdpi.com
Ventricular arrhythmias, mainly lethal arrhythmias, such as ventricular tachycardia and
fibrillation, may lead to sudden cardiac death. These are triggered as a result of cardiac …

Atrial fibrillation–mediated cardiomyopathy

D Qin, MC Mansour, JN Ruskin… - Circulation: Arrhythmia …, 2019 - Am Heart Assoc
AF-mediated cardiomyopathy (AMC) is an important reversible cause of heart failure that is
likely underdiagnosed in today's clinical practice. AMC describes AF either as the sole …