Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Nature has evolved strategies to encode information within a single biopolymer to program
biomolecular interactions with characteristic stoichiometry, orthogonality and …

We describe a Hi-C-based method, Micro-C, in which micrococcal nuclease is used instead
of restriction enzymes to fragment chromatin, enabling nucleosome resolution chromosome …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional
regulation and other DNA-related biological processes. Here, we report the 11-angstrom …

The human genome is segmented into topologically associating domains (TADs), but the
role of this conserved organization during transient changes in gene expression is not …

The fractal globule is a compact polymer state that emerges during polymer condensation as
a result of topological constraints which prevent one region of the chain from passing across …