Acoustofluidics for biomedical applications

J Rufo, F Cai, J Friend, M Wiklund… - Nature Reviews Methods …, 2022 - nature.com
Acoustofluidic technologies utilize acoustic waves to manipulate fluids and particles within
fluids, all in a contact-free and biocompatible manner. Over the past decade, acoustofluidic …

Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

Acoustofluidic separation of cells and particles

M Wu, A Ozcelik, J Rufo, Z Wang, R Fang… - Microsystems & …, 2019 - nature.com
Acoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research
field that is addressing challenges in biology, medicine, chemistry, engineering, and …

Acoustic microfluidics

P Zhang, H Bachman, A Ozcelik… - Annual Review of …, 2020 - annualreviews.org
Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro-
or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device …

Microfluidic‐based approaches in targeted cell/particle separation based on physical properties: fundamentals and applications

R Nasiri, A Shamloo, S Ahadian, L Amirifar, J Akbari… - Small, 2020 - Wiley Online Library
Cell separation is a key step in many biomedical research areas including biotechnology,
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …

Microfluidic-based technologies for CTC isolation: a review of 10 years of intense efforts towards liquid biopsy

L Descamps, D Le Roy, AL Deman - International Journal of Molecular …, 2022 - mdpi.com
The selection of circulating tumor cells (CTCs) directly from blood as a real-time liquid
biopsy has received increasing attention over the past ten years, and further analysis of …

[HTML][HTML] Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus–associated oropharyngeal cancer detection

Z Wang, F Li, J Rufo, C Chen, S Yang, L Li… - The Journal of Molecular …, 2020 - Elsevier
Previous efforts to evaluate the detection of human papilloma viral (HPV) DNA in whole
saliva as a diagnostic measure for HPV-associated oropharyngeal cancer (HPV-OPC) have …

Surface acoustic waves in biosensing applications

Y Huang, PK Das, VR Bhethanabotla - Sensors and Actuators Reports, 2021 - Elsevier
In this paper, we review the utilization of surface acoustic waves in biosensing applications.
A brief background on the theoretical aspects and on the modeling principles for acoustic …

Methodologies, technologies, and strategies for acoustic streaming-based acoustofluidics

M Stringer, Z Zeng, X Zhang, Y Chai, W Li… - Applied Physics …, 2023 - pubs.aip.org
Acoustofluidics offers contact-free manipulation of particles and fluids, enabling their uses in
various life sciences, such as for biological and medical applications. Recently, there have …

Greatly enhanced CTC culture enabled by capturing CTC heterogeneity using a PEGylated PDMS–Titanium–Gold electromicrofluidic device with glutathione …

EA Kwizera, W Ou, S Lee, S Stewart, JG Shamul, J Xu… - ACS …, 2022 - ACS Publications
The circulating tumor cells (CTCs, the root cause of cancer metastasis and poor cancer
prognosis) are very difficult to culture for scale-up in vitro, which has hampered their use in …