The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease

T Zuo, SC Ng - Frontiers in microbiology, 2018 - frontiersin.org
In the twenty first century, the changing epidemiology of inflammatory bowel disease (IBD)
globally with increasing disease incidence across many countries relates to the altered gut …

mixOmics: An R package for 'omics feature selection and multiple data integration

F Rohart, B Gautier, A Singh… - PLoS computational …, 2017 - journals.plos.org
The advent of high throughput technologies has led to a wealth of publicly available 'omics
data coming from different sources, such as transcriptomics, proteomics, metabolomics …

The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer's disease—a critical review

M Sochocka, K Donskow-Łysoniewska, BS Diniz… - Molecular …, 2019 - Springer
One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

Microbiota: a key orchestrator of cancer therapy

S Roy, G Trinchieri - Nature Reviews Cancer, 2017 - nature.com
The microbiota is composed of commensal bacteria and other microorganisms that live on
the epithelial barriers of the host. The commensal microbiota is important for the health and …

Regulation of inflammation by microbiota interactions with the host

JM Blander, RS Longman, ID Iliev, GF Sonnenberg… - Nature …, 2017 - nature.com
The study of the intestinal microbiota has begun to shift from cataloging individual members
of the commensal community to understanding their contributions to the physiology of the …

The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

JF Bach - Nature Reviews Immunology, 2018 - nature.com
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …

Peptidoglycan recognition by the innate immune system

AJ Wolf, DM Underhill - Nature Reviews Immunology, 2018 - nature.com
The innate immune system recognizes microbial products using germline-encoded
receptors that initiate inflammatory responses to infection. The bacterial cell wall component …

The effectiveness of probiotics in the treatment of inflammatory bowel disease (IBD)—a critical review

D Jakubczyk, K Leszczyńska, S Górska - Nutrients, 2020 - mdpi.com
Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two
separate diseases: Crohn's disease (CD) and ulcerative colitis (UC). Although the …

Mining the microbiota for microbial and metabolite-based immunotherapies

AN Skelly, Y Sato, S Kearney, K Honda - Nature Reviews Immunology, 2019 - nature.com
Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract
each day, collectively producing thousands of small molecules and metabolites with local …