Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …

A hostile microenvironment in tumor tissues disrupts endoplasmic reticulum homeostasis
and induces the unfolded protein response (UPR). A chronic UPR in both cancer cells and …

CARM1 is often overexpressed in human cancers including in ovarian cancer. However,
therapeutic approaches based on CARM1 expression remain to be an unmet need. Cancer …

In recent years, most of our knowledge about myeloid derived suppressor cells (MDSCs)
has come from cancer studies, which depicts Yin side of MDSCs. In cancer, inherent …

The immunosuppressive tumor microenvironment (TME) supports the development of
tumors and limits tumor immunotherapy, including hematological malignancies …

The SWI/SNF chromatin-remodeling complex is frequently altered in human cancers. For
example, the SWI/SNF component ARID1A is mutated in more than 50% of ovarian clear cell …

The lymph node (LN) is an essential tissue for achieving effective immune responses but it is
also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude …

The complement cascade consists of cell bound and serum proteins acting together to
protect the host from pathogens, remove cancerous cells and effectively links innate and …

Chronic lymphocytic leukemia (CLL) is a heterogeneous B cell malignancy characterized by
the accumulation of functionally incompetent B lymphocytes. Despite the availability of …