Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and
the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step …

▪ Abstract We review how motile cells regulate actin filament assembly at their leading edge.
Activation of cell surface receptors generates signals (including activated Rho family …

Brief periods of sleep loss have long-lasting consequences such as impaired memory
consolidation. Structural changes in synaptic connectivity have been proposed as a …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Soluble β-amyloid (Aβ) oligomers impair synaptic plasticity and cause synaptic loss
associated with Alzheimer's disease (AD). We report that murine PirB (paired …

The leading edge (∼ 1 μm) of lamellipodia in Xenopus laevis keratocytes and fibroblasts
was shown to have an extensively branched organization of actin filaments, which we term …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

▪ Abstract Ubiquitous among eukaryotes, the ADF/cofilins are essential proteins responsible
for the high turnover rates of actin filaments in vivo. In vertebrates, ADF and cofilin are …

The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of
actin dynamics. In contrast to the mechanisms of inactivation of ADF/cofilin by kinases such …

In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin
phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is …