Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Cardiovascular diseases are described as the leading cause of morbidity and mortality in
modern societies. Therefore, the importance of cardiovascular diseases prevention is widely …

The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …

The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …

Stroke is the most common cause of disability globally. Neural stem cell (NSC) therapy,
which can replace lost and damaged neurons, has been proposed as a potential treatment …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

Current understanding on the mechanisms of brain injury and neurodegeneration highlights
an appreciation of multicellular interactions within the neurovascular unit (NVU), which …

Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue
that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic …

Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …