Lipoprotein‐associated phospholipase A2: the story continues

F Huang, K Wang, J Shen - Medicinal research reviews, 2020 - Wiley Online Library
Inflammation is thought to play an important role in the pathogenesis of vascular diseases.
Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation …

Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2

A Nikolaou, MG Kokotou, S Vasilakaki… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

Biology and biochemistry of platelet-activating factor

JT O'Flaherty, RL Wykle - Clinical Reviews in Allergy, 1983 - Springer
Platelet-activating factor (PAF) is an endogenously formed phospholipid with extremely toxic
actions, whose chemical characterization was completed in 1979. This article reviews its …

Mediterranean diet and platelet-activating factor; a systematic review

T Nomikos, E Fragopoulou, S Antonopoulou… - Clinical …, 2018 - Elsevier
Platelet-activating factor (PAF) is a glycerylether lipid and one of the most potent
endogenous mediators of inflammation. Through its binding to a well-characterized receptor …

4-Amino-TEMPO loaded liposomes as sensitive EPR and OMRI probes for the detection of phospholipase A2 activity

D Alberti, E Thiaudiere, E Parzy, S Elkhanoufi… - Scientific Reports, 2023 - nature.com
This work aims at developing a diagnostic method based on Electron Paramagnetic
Resonance (EPR) measurements of stable nitroxide radicals released from “EPR silent” …

Establishment and clinical application of time-resolved immunofluorescence assay of lipoprotein-associated phospholipase A2

X Chen, K Zhou, Z Xiang, X Zhou, Y Wang, J Hong… - Analytical …, 2022 - Elsevier
Aim This study aimed to establish a highly sensitive time-resolved fluorescence
immunoassay (TRFIA) for the detection of serum lipoprotein-associated phospholipase A2 …

Measurement of lipoprotein-associated phospholipase A2 by use of 3 different methods: exploration of discordance between ELISA and activity assays

C Topbas, A Swick, M Razavi, NL Anderson… - Clinical …, 2018 - academic.oup.com
BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme
associated with inflammation, is used as a biomarker for cardiovascular disease risk. Both …

Endothelial dysfunction in children with obstructive sleep apnea is associated with elevated lipoprotein‐associated phospholipase A2 plasma activity levels

L Kheirandish‐Gozal, MF Philby, Z Qiao… - Journal of the …, 2017 - Am Heart Assoc
Background Obstructive sleep apnea (OSA) is a highly prevalent condition, especially in
obese children, and has been associated with increased risk for endothelial dysfunction and …

Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: a systematic review

A Younus, C Humayun, R Ahmad, O Ogunmoroti… - Journal of clinical …, 2017 - Elsevier
Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits
proinflammatory properties and has been associated with subclinical cardiovascular …

Elevated lipoprotein-associated phospholipase A2 is associated with intracranial atherosclerosis

Y Wang, G Liu, H Song, C Cao, X Ji, G Cao - Frontiers in Neurology, 2022 - frontiersin.org
Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory factor
in the pathogenesis of atherosclerotic plaque and is associated with an increased risk of …