Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

Advances in HER2-targeted therapies have improved the survival of patients with HER2-
positive breast cancer. The standard-of-care treatment for localized disease has been …

Single-cell and spatial technologies that profile gene expression across a whole tissue are
revolutionizing the resolution of molecular states in clinical samples. Current commercially …

Introduction Extensive research is directed to uncover new biomarkers capable to stratify
breast cancer patients into clinically relevant cohorts. However, the overall performance …

Background Adjuvant abemaciclib combined with endocrine therapy (ET) previously
demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) …

Deep learning architecture with convolutional neural network achieves outstanding success
in the field of computer vision. Where U-Net has made a great breakthrough in biomedical …

Single-cell analyses have revealed extensive heterogeneity between and within human
tumours,,–, but complex single-cell phenotypes and their spatial context are not at present …

Purpose To provide current recommendations about fertility preservation for adults and
children with cancer. Methods A systematic review of the literature published from January …

Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form
ecosystems that determine disease progression and response to therapy. To characterize …

Background Patients who have residual invasive carcinoma after the receipt of neoadjuvant
chemotherapy for human epidermal growth factor receptor 2 (HER2)–negative breast cancer …