Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

The combat against the Corona virus disease of 2019 (COVID-19), has created a chaos
among the healthcare institutions and researchers, in turn accelerating the dire need to …

Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …

The past decade has witnessed a revival of interest in the hormone melatonin, partly
attributable to the discovery that genetic variation in MTNR1B–the melatonin receptor gene …

Ionizing radiation (IR) has found widespread application in modern medicine, including
medical imaging and radiotherapy. As a result, both patients and healthcare professionals …

Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …