Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

B-cell translocation gene 2 (BTG2), the first gene identified in the BTG/TOB gene family, is
involved in many biological activities in cancer cells acting as a tumor suppressor. The BTG2 …

Background Epigenetic alterations have been shown to contribute immensely to human
carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification …

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …

Our understanding of the DNA damage responses of human cells to radiation has increased
remarkably over the recent years although some notable signaling events remain to be …

Breast cancer is the most commonly diagnosed female cancer in the world. Though
therapeutic treatments are available to treat breast cancer and in some instances are …

Background Subcortical ischemic vascular dementia, one of the major subtypes of vascular
dementia, is characterized by lacunar infarcts and white matter lesions caused by chronic …

B‑cell translocation gene 2 (BTG2) is a tumor suppressor gene, which belongs to the anti‑
proliferation gene family. Our previous study demonstrated that microRNA (miR)‑21 and the …

Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic
recombination-related gene MRE11 (meiotic recombination 11) is essential for preserving …

Antiproliferative BTG/Tob proteins interact directly with the CAF1 deadenylase subunit of the
CCR4-NOT complex. This binding requires the presence of two conserved motifs, boxA and …