Human de novo purine biosynthesis
The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …
enzymes are enumerated, as well as the reactions they catalyze and their physical …
The purinosome: a case study for a mammalian metabolon
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …
[HTML][HTML] The mammalian purine salvage pathway as an exploitable route for cerebral bioenergetic support after brain injury
P Gessner, J Lum, BG Frenguelli - Neuropharmacology, 2023 - Elsevier
Purine-based molecules play ancient, fundamental, and evolutionarily-conserved roles
across life on Earth, ranging from DNA and RNA, to the universal energy currency, ATP. In …
across life on Earth, ranging from DNA and RNA, to the universal energy currency, ATP. In …
Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes
CA Mangold, MM Rathbun, DW Renner… - PLoS …, 2021 - journals.plos.org
Infection with herpes simplex virus 1 (HSV-1) occurs in over half the global population,
causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate …
causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate …
Targeting purine metabolism-related enzymes for therapeutic intervention: A review from molecular mechanism to therapeutic breakthrough
D Wu, S Yang, C Yuan, K Zhang, J Tan, K Guan… - International Journal of …, 2024 - Elsevier
Purines are ancient metabolites with established and emerging metabolic and non-
metabolic signaling attributes. The expression of purine metabolism-related genes is …
metabolic signaling attributes. The expression of purine metabolism-related genes is …
Life and work of stress granules and processing bodies: new insights into their formation and function
M Perez-Pepe, AJ Fernández-Alvarez… - Biochemistry, 2018 - ACS Publications
The dynamic formation of stress granules (SGs), processing bodies (PBs), and related RNA
organelles regulates diverse cellular processes, including the coordination of functionally …
organelles regulates diverse cellular processes, including the coordination of functionally …
Induced pluripotent stem cells from subjects with Lesch-Nyhan disease
DJ Sutcliffe, AR Dinasarapu, JE Visser, J Hoed… - Scientific reports, 2021 - nature.com
Lesch-Nyhan disease (LND) is an inherited disorder caused by pathogenic variants in the
HPRT1 gene, which encodes the purine recycling enzyme hypoxanthine–guanine …
HPRT1 gene, which encodes the purine recycling enzyme hypoxanthine–guanine …
Genomic binding patterns of forkhead box protein O1 reveal its unique role in cardiac hypertrophy
Background: Cardiac hypertrophic growth is mediated by robust changes in gene
expression and changes that underlie the increase in cardiomyocyte size. The former is …
expression and changes that underlie the increase in cardiomyocyte size. The former is …
Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets
C Zeng, J Xie, J Liu, XH Chen - Frontiers in Oncology, 2024 - frontiersin.org
The core of tumor cell metabolism is the management of energy metabolism due to the
extremely high energy requirements of tumor cells. The purine nucleotide synthesis pathway …
extremely high energy requirements of tumor cells. The purine nucleotide synthesis pathway …
Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS
Phosphoribosylformylglycinamidine synthase (PFAS) is an essential enzyme in de novo
synthesis of purine. Previously, PFAS has been reported to modulate RIG-I activation during …
synthesis of purine. Previously, PFAS has been reported to modulate RIG-I activation during …