Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable
of generating 2′-deoxynucleotides de novo and are thus critical in DNA biosynthesis and …

Radicals in biology, once thought to all be bad actors, are now known to play a central role
in many enzymatic reactions. Of the known radical-based enzymes, ribonucleotide …

In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase
(RNR), the enzyme responsible for biosynthesis of the 2′-deoxynucleotide building blocks …

Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides using
radical-based chemistry. For class Ia RNRs, the radical species is stored in a separate …

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to
deoxyribonucleotides, thereby playing a key role in DNA replication and repair. Escherichia …

Ribonucleotide reductase (RNR) is an essential enzyme that converts ribonucleotides to
deoxyribonucleotides and is a promising antibiotic target, but few RNRs have been …

Ribonucleotide reductases (RNRs) catalyze the conversion of all four ribonucleotides to
deoxyribonucleotides and are essential for DNA synthesis in all organisms. The active form …

The mechanistic enzymology of oxidoreductases has contributed to the development of
therapeutics, biomimetic synthetic catalysts, and engineered enzymes with improved or …