Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Hypopituitarism refers to deficiency of one or more hormones produced by the anterior
pituitary or released from the posterior pituitary. Hypopituitarism is associated with excess …

Objective: The development of these guidelines is sponsored by the American Association
of Clinical Endocrinologists (AACE) Board of Directors and American College of …

Growth hormone (GH) is important for promotion of somatic growth and the regulation of
substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver …

Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

Abstract Context Long-acting GH (LAGH) preparations are currently being developed in an
attempt to improve adherence. The profile of GH action following administration of LAGH …

Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical
practice more than 20 years ago. Since then, a great volume of experience has been …

Objectives Preliminary data from the French cohort of the Safety and Appropriateness of
Growth hormone treatments in Europe (SAG hE) study raised concerns regarding the safety …

Objective Few studies have determined the effects of more than 5–10 years of GH
replacement in adults on body composition and cardiovascular risk factors. Design/patients …

Context Data on long-term safety of growth hormone (GH) replacement in adults with GH
deficiency (GHD) are needed. Objective We aimed to evaluate the safety of GH in the full …