Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Histone post-transcriptional modifications play essential roles in regulation of all DNA
related processes. Among them, histone ubiquitination has been discovered for more than …

Various factors differentially recognize trimethylated histone H3 lysine 4 (H3K4me3) near
promoters, H3K4me2 just downstream, and promoter-distal H3K4me1 to modulate gene …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

The SAGA (Spt–Ada–Gcn5 acetyltransferase) coactivator complex contains distinct
chromatin-modifying activities and is recruited by DNA-bound activators to regulate the …

Elucidating the global and local rules that govern genome-wide, hierarchical chromatin
architecture remains a critical challenge. Current high-throughput chromosome …

Nucleosomal organization in and around genes may contribute substantially to
transcriptional regulation. The contribution of histone modifications to genome-wide …

The five-subunit yeast Paf1 complex (Paf1C) regulates all stages of transcription and is
critical for the monoubiquitylation of histone H2B (H2Bub), a modification that broadly …