Conspectus Pore forming toxins (PFTs) are the largest class of bacterial toxins playing a
central role in bacterial pathogenesis. They are proteins specifically designed to form …

Interaction of proteins with charged macromolecules is involved in many processes in cells.
Firstly, there are many naturally occurred charged polymers such as DNA and RNA …

One of the major challenges of nanomedicine and gene therapy is the effective translocation
of drugs and genes across cell membranes. In this study, we describe a systematic …

Abstract SLC20A1/PiT1 is a sodium-dependent inorganic phosphate transporter, initially
recognized as the retroviral receptor for Gibbon Ape Leukemia Virus in humans. SNPs in …

Abstract The N, N'-(1, 2-phenylene) bis (1-(4-chlorophenyl) methanimine)(CS4) was
synthesized and characterized by infrared (IR), absorption (UV-vis) and NMR (1H and 13C) …

The understanding of dendrimer interactions with cell membranes has great importance in
drug/gene delivery based therapeutics. Although molecular simulations have been used to …

Membrane protein molecules can self-assemble to form a single-biomolecule interface,
which can accommodate one single molecule at a time and provide a suitable sensing …

Protein engineering by directed evolution is time-consuming. Hence, in silico techniques like
FoldX-Yasara for∆∆ G calculation, and SNPeffect for predicting propensity for aggregation …

Protein membrane interactions play an important role in our understanding of diverse
phenomena ranging from membrane-assisted protein aggregation to oligomerization and …

Novel structurally intriguing heterocycles embedded with spiropyrrolidine, quinoxaline and
chromanone units were synthesized in good yields using a [Bmim] Br accelerated …