The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …

The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

Despite recent advances in the understanding of morphological evolution, the genetic
underpinnings of behavioral and physiological evolution remain largely unknown. Here, we …

In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided
degradation of messenger RNA transcripts, has had an important impact on identifying and …

Despite the importance of insulin signaling pathways in human disease, initial concerns that
insect physiology and sugar metabolism differ enough from humans that flies would not …

Mitochondrial (mtDNA) and nuclear genes have to operate in a coordinated manner to
maintain organismal function, and the regulation of this homeostasis presents a substantial …

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely
related species, populations, and individuals can display dramatic variation in diet. Here we …

Adaptation to environmental stress is critical for long-term species persistence. With climate
change and other anthropogenic stressors compounding natural selective pressures …