The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

Diabetes represents a spectrum of disease in which metabolic dysfunction damages
multiple organ systems including liver, kidneys and peripheral nerves,. Although the onset …

Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite
significant progress in understanding the genetic aetiologies of DCM, the molecular …

The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse
biosynthetic functions. While some tumors can synthesize serine de novo, others are …

Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient
supply during fasting and other stresses. These pathways are regulated locally in tissues …

Cancer cells may depend on exogenous serine, depletion of which results in slower growth
and activation of adaptive metabolic changes. We previously demonstrated that serine and …

Retinopathy of prematurity is defined as retinal abnormalities that occur during development
as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth …

Purpose FLVCR1 encodes a solute carrier protein implicated in heme, choline, and
ethanolamine transport. Although Flvcr1−/− mice exhibit skeletal malformations and …

In the brain, the non‐essential amino acid L‐serine is produced through the phosphorylated
pathway (PP) starting from the glycolytic intermediate 3‐phosphoglycerate: among the …