The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional
repressor that is of fundamental importance across species, as evident by its evolutionary …

MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence,
development, invasion and metastasis in many kinds of solid tumors and hematologic …

Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in
innate lymphopoiesis is unknown. Using conditional genetic inactivation, we show that …

Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals.
Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and …

Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the
lifespan, yet how this common congenital infection modulates developing fetal immune cell …

Natural killer (NK) cells are essential for early protection against virus infection and must
metabolically adapt to the energy demands of activation. Here, we found upregulation of the …

NK cells are short‐lived innate lymphocytes that can mediate antigen‐independent
responses to infection and cancer. However, studies from the past two decades have shown …

Transcription factors are nuclear proteins that control the rate of gene expression, activating
or repressing transcription in a context-dependent manner. These regulators lie at the heart …

Natural killer (NK) cells are essential for early protection against virus infection and must
metabolically adapt to the energy demands of activation. Here, we found upregulation of the …

Background: Atrial fibrillation (AF) is associated with high mortality and morbidity rates. In
terms of the underlying pathophysiology, AF is complex and remains unclear. Necroptosis …