Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Proteasome dependency is a feature of many cancers that can be targeted by proteasome
inhibitors. For some cancer types, notably breast cancer and triple-negative breast cancer …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

The KMT2A (formerly MLL) encodes the histone lysine-specific N-methyltransferase 2A and
is mapped on chromosome 11q23. KMT2A is a frequent target for recurrent translocations in …

Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of
multiple B-cell malignancies. These agents have also been employed with success in the …

Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as
prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research. In …

Adult T-cell leukemia/lymphoma (ATLL), an infrequent malignancy resultant from human T-
cell lymphotropic virus type I (HTLV-1), exhibits a spectrum of phenotypes, encompassing …

Pharmacologic targeting of chromatin-associated protein complexes has shown significant
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …