▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Transcription and splicing are functionally coupled, resulting in highly efficient splicing of
RNA polymerase II (RNAP II) transcripts. The mechanism involved in this coupling is not …

Coupling between transcription and RNA processing is a key gene regulatory mechanism.
Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation …

Nearly 97% of the human genome is composed of noncoding DNA, which varies from one
species to another. Changes in these sequences often manifest themselves in clinical and …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Processing of RNA precursors to their mature form often occurs co-transcriptionally.
Consequently, the ternary complex of DNA template, RNA polymerase and nascent RNA …

Pre-mRNA splicing is coupled to transcription by RNA polymerase II (RNAP II). We
previously showed that U1 small nuclear ribonucleoprotein (snRNP) associates with RNAP …

Defects at the level of the pre-mRNA splicing process represent a major cause of human
disease. Approximately 15–50% of all human disease mutations have been shown to alter …

Pre-mRNA splicing is functionally coupled to transcription, and genotoxic stresses can
enhance alternative exon inclusion by affecting elongating RNA polymerase II. We report …