The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
Q Zhang, Y Zhu, X Cao, W Tan, J Yu, Y Lu, R Kang… - Molecular Cancer, 2023 - Springer
PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are
significant in development and reproduction of organisms. Recently, emerging evidences …
significant in development and reproduction of organisms. Recently, emerging evidences …
PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA
L Tan, D Mai, B Zhang, X Jiang, J Zhang, R Bai, Y Ye… - Molecular cancer, 2019 - Springer
Background Breast cancer is one of the most common malignancies and the major cause of
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …
Editorial focus: understanding off-target effects as the key to successful RNAi therapy
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
Piwi-interacting RNAs in cancer: emerging functions and clinical utility
PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally
described in the germline, there are over 20,000 piRNA genes in the human genome. In …
described in the germline, there are over 20,000 piRNA genes in the human genome. In …
[HTML][HTML] piRNA-823 is a novel potential therapeutic target in aortic dissection
M Li, G Li, Y Yang, J Zong, X Fu, ALH Htet, X Li… - Pharmacological …, 2023 - Elsevier
Aortic dissection (AD) presents a medical challenge for clinicians. Here, to determine the
role of a novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from …
role of a novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from …
[HTML][HTML] PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma
D Mai, P Ding, L Tan, J Zhang, Z Pan, R Bai, C Li… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Although PIWI-interacting RNAs (piRNAs) have recently been linked to human
diseases, their roles and functions in malignancies remain unclear. This study aimed to …
diseases, their roles and functions in malignancies remain unclear. This study aimed to …
[PDF][PDF] PIWI proteins and PIWI-interacting RNA: emerging roles in cancer
YN Han, Y Li, SQ Xia, YY Zhang, JH Zheng… - Cellular Physiology and …, 2018 - karger.com
P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …
The function of non-coding RNAs in lung cancer tumorigenesis
C Braicu, AA Zimta, A Harangus, I Iurca, A Irimie… - Cancers, 2019 - mdpi.com
Lung cancer is the most prevalent and deadliest cancer worldwide. A significant part of lung
cancer studies is dedicated to the expression alterations of non-coding RNAs. The non …
cancer studies is dedicated to the expression alterations of non-coding RNAs. The non …