Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

Y Zhang, X Liang, X Bao, W Xiao, G Chen - European journal of medicinal …, 2022 - Elsevier
Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …

Recent clinical trends in Toll‐like receptor targeting therapeutics

MA Anwar, M Shah, J Kim, S Choi - Medicinal research reviews, 2019 - Wiley Online Library
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Intestinal phages interact with bacteria and are involved in human diseases

H Shuwen, D Kefeng - Gut Microbes, 2022 - Taylor & Francis
Phages are the most abundant and diverse biological entities on Earth and exert specific
effects on bacterial hosts. The coexistence of phages and bacteria in the intestinal tract is …

Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism

T Chen, Q Li, J Wu, Y Wu, W Peng, H Li, J Wang… - Cancer Immunology …, 2018 - Springer
Fusobacterium nucleatum (Fn) has been shown to promote colorectal cancer (CRC)
development by inhibiting host anti-tumour immunity. However, the impact of Fn infection on …

[HTML][HTML] Mutations in the SARS-CoV-2 spike RBD are responsible for stronger ACE2 binding and poor anti-SARS-CoV mAbs cross-neutralization

M Shah, B Ahmad, S Choi, HG Woo - Computational and Structural …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), is a novel beta coronavirus. SARS-CoV-2 uses spike …

High mobility group box-1 (HMGb1): current wisdom and advancement as a potential drug target: miniperspective

S VanPatten, Y Al-Abed - Journal of medicinal chemistry, 2017 - ACS Publications
High mobility group box-1 (HMGb1) protein, a nuclear non-histone protein that is released or
secreted from the cell in response to damage or stress, is a sentinel for the immune system …

Molecular mechanism underlying the TLR4 antagonistic and antiseptic activities of papiliocin, an insect innate immune response molecule

M Krishnan, J Choi, A Jang, S Choi… - Proceedings of the …, 2022 - National Acad Sciences
Antimicrobial peptides are innate immune molecules playing essential roles in insects,
which lack the adaptive immune system. Insects possess Toll9, the innate pattern …

Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization

C Li, Y Gan, Z Li, M Fu, Y Li, X Peng, Y Yang… - Biomaterials …, 2023 - Springer
Background P. aeruginosa, a highly virulent Gram-negative bacterium, can cause severe
nosocomial infections, and it has developed resistance against most antibiotics. New …

Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling

S Chei, HJ Oh, JH Song, YJ Seo, K Lee, KJ Kim… - Scientific reports, 2020 - nature.com
The blue-green alga Spirulina maxima is a microscopic filamentous cyanobacterium.
Spirulina was recently reported to elicit beneficial effects such as reducing cholesterol and …

[HTML][HTML] Protective effects of berberine in chronic copper-induced liver and gill injury in freshwater grouper (Acrossocheilus fasciatus)

C Wang, L Wang, L Yang, C Gao, B Wang… - Ecotoxicology and …, 2023 - Elsevier
This experiment aimed to investigate the protective effects of berberine on copper-induced
liver and gill toxicities in freshwater grouper (Acrossocheilus fasciatus). Fish (initial weight …