Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …

The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase
underpinned by timely and spatially controlled secretion of apical organelles termed …

The asexual blood stages of Plasmodium falciparum cause the most lethal form of human
malaria. During growth within an infected red blood cell, parasite multiplication and …

P lasmodium spp. and T oxoplasma gondii are important human and veterinary pathogens.
These parasites possess an unusual double membrane structure located directly below the …

Mitochondria distribution in cells controls cellular physiology in health and disease. Here we
describe the mitochondrial morphology and positioning found in the different stages of the …

Apicomplexan parasites include the causative agents of malaria and toxoplasmosis. Cell-
based screens in Toxoplasma previously identified a chemical modulator of calcium …

Pathology of the most lethal form of malaria is caused by Plasmodium falciparum asexual
blood stages and initiated by merozoite invasion of erythrocytes. We present a …

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites.
Many apicomplexan protein kinases are substantially different from their mammalian …

Apicomplexan parasites have challenged researchers for nearly a century. A major
challenge to developing efficient treatments and vaccines is the parasite's ability to change …