The significance of NLRP inflammasome in neuropsychiatric disorders
Y Shen, L Qian, H Luo, X Li, Y Ruan, R Fan, Z Si… - Brain Sciences, 2022 - mdpi.com
The NLRP inflammasome is a multi-protein complex which mainly consists of the nucleotide-
binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is …
binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is …
[HTML][HTML] CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological …
J Li, H Wang, D Liu, X Li, L He, J Pan, Q Shen… - Brain, Behavior, and …, 2023 - Elsevier
Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …
Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions
R Liu, B Zhao, J Zhao, M Zhang - The American Journal of Drug …, 2024 - Taylor & Francis
Background: Ethanol exposure has been suggested to be implicated in the initiation and
progression of several non-communicable diseases (NCD), including neurological …
progression of several non-communicable diseases (NCD), including neurological …
Levetiracetam attenuates experimental ulcerative colitis through promoting Nrf2/HO-1 antioxidant and inhibiting NF-κB, proinflammatory cytokines and iNOS/NO …
K Amirshahrokhi, M Imani - International Immunopharmacology, 2023 - Elsevier
Ulcerative colitis (UC) is a serious inflammatory disease of the colon. The pathogenic
mechanisms of UC involve the activation of inflammatory and oxidative stress responses in …
mechanisms of UC involve the activation of inflammatory and oxidative stress responses in …
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired …
X Lin, H Wang, L Zou, B Yang, W Chen, X Rong… - Free Radical Biology …, 2024 - Elsevier
Background Chronic alcohol exposure induces cognitive impairment and NLRP3
inflammasome activation in the mPFC (medial prefrontal cortex). Mitophagy plays a crucial …
inflammasome activation in the mPFC (medial prefrontal cortex). Mitophagy plays a crucial …
Liver injury induced by exposure to polystyrene microplastics alone or in combination with cadmium in mice is mediated by oxidative stress and apoptosis
S Sheng, N Han, Y Wei, J Wang, W Han, B Xing… - … Trace Element Research, 2024 - Springer
Microplastics (MPs) have been considered an emerging environmental pollutant which,
when combined with toxic metals, enter the circulatory system of mammals and eventually …
when combined with toxic metals, enter the circulatory system of mammals and eventually …
Carvedilol attenuates brain damage in mice with hepatic encephalopathy
K Amirshahrokhi, A Niapour - International Immunopharmacology, 2022 - Elsevier
Brain injury is the most common and serious consequence of hepatic encephalopathy (HE),
and its pathophysiology is poorly understood. Excessive inflammatory, oxidative and …
and its pathophysiology is poorly understood. Excessive inflammatory, oxidative and …
Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways
X Jiang, Q Yan, W Lao, Q Lin, H Cao, L Chen… - Metabolic Brain …, 2023 - Springer
This study aims to investigate the effect of irisin on ethanol-induced behavioral deficits and
explore the underlying mechanisms. A mouse model of ethanol addiction/withdrawal was …
explore the underlying mechanisms. A mouse model of ethanol addiction/withdrawal was …
Systemic toxicity of biodegradable polyglycolic acid microplastics on the gut-liver-brain axis in zebrafish
J Luan, L Wen, Y Bao, H Bai, C Zhao, S Zhang… - Science of The Total …, 2024 - Elsevier
Polyglycolic acid (PGA), a novel type of hazardous biodegradable plastic, is gradually being
widely used in the biomedical and food packaging industries. However, the long-term …
widely used in the biomedical and food packaging industries. However, the long-term …
Therapeutic Effect of Levetiracetam Against Thioacetamide-Induced Hepatic Encephalopathy Through Inhibition of Oxidative Stress and Downregulation of NF-κB …
K Amirshahrokhi, M Imani - Inflammation, 2024 - Springer
Hepatic encephalopathy (HE) is a serious brain disorder which associated with neurological
and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play …
and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play …