Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

Ubiquitylation is a posttranslational modification of proteins that is necessary for a variety of
cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 …

Background Oxidative stress, apoptosis, and fibrosis have important roles in acute
myocardial infarction, which is the main cause of global morbidity and mortality. Guanxin V …

Hepatocarcinogenesis is a complex multistep biological process involving genetic and
epigenetic alterations that are accompanied by activation of oncoproteins and inactivation of …

In cancer research, oncogenesis can be affected by modulating the deubiquitination
pathway. Ubiquitination regulates proteins post-translationally in variety of physiological …

Transactivation response DNA‐binding protein of 43 kDa (TDP‐43) is a major constituent of
cytoplasmic aggregates in neuronal and glial cells in cases of amyotrophic lateral sclerosis …

Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal
carcinoma, but the exact regulatory mechanism underlying chemoresistance in …

Background Human malignancies are composed of heterogeneous subpopulations of
cancer cells with phenotypic and functional diversity. Among them, a unique subset of …

Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very
aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer …

The formation of misfolded protein aggregates is one of the pathological hallmarks of
neurodegenerative diseases. We have previously demonstrated the cytoplasmic aggregate …