Stem cell-based embryo models offer unprecedented experimental tools for studying early
human development. The usefulness of embryo models hinges on their molecular, cellular …

The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

Congenital infections are a leading preventable cause of pregnancy complications
impacting both mother and fetus. Although advancements have been made in …

Human trophoblast organoids provide a valuable in vitro system to investigate human
placental development and function. In this issue of Developmental Cell, Shannon et al …

The placental DNA methylation landscape is unique, with widespread partially methylated
domains (PMDs). The placental" methylome" is conserved across mammals, a shared …

Introduction Selecting an in vitro culture model of the human placenta is challenging due to
representation of different trophoblast cell types with distinct biological roles and limited …

The outer surface of chorionic villi in the human placenta consists of a single multinucleated
cell called the syncytiotrophoblast (STB). The unique cellular ultrastructure of the STB …

Organoid technology, as a revolutionary biomedical tool, has shown immense potential in
haematological research in recent years. By using three‐dimensional (3D) cell culture …

The management of neurological disorders heavily relies on neurotherapeutic drugs, but
notable concerns exist regarding their possible negative effects on reproductive health …

Background Organoids are stem-cell derived, self-organised, three-dimensional cultures
that improve in vitro recapitulation of tissue structure. The generation of trophoblast …