Synthesis and therapeutic potential of imidazole containing compounds

A Siwach, PK Verma - BMC chemistry, 2021 - Springer
Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen,
four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole. It contains two …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Synthesis and characterization of new Cr (III), Fe (III) and Cu (II) complexes incorporating multi-substituted aryl imidazole ligand: Structural, DFT, DNA binding, and …

AM Abu-Dief, LH Abdel-Rahman… - … Acta Part A: Molecular …, 2020 - Elsevier
Designing new metal-based molecular antibiotics is an efficient approach to overcome the
growing threat of antimicrobial resistance. In this paper, novel Cr (III), Fe (III) and Cu (II) …

Cobalt nanocomposites on N-doped hierarchical porous carbon for highly selective formation of anilines and imines from nitroarenes

T Song, P Ren, Y Duan, Z Wang, X Chen, Y Yang - Green Chemistry, 2018 - pubs.rsc.org
The search for active, inexpensive, and stable heterogeneous catalysts for organic
transformation still remains challenging in both academia and industry. Herein, we present …

Recent advances in heterogeneous catalysts for the synthesis of imidazole derivatives

N Kerru, SVHS Bhaskaruni, L Gummidi… - Synthetic …, 2019 - Taylor & Francis
Among the bioactive heterocyclic frameworks, nitrogen containing multisubstituted
imidazoles are versatile building blocks of many naturally occurring products. Imidazoles …

Synthesis, spectral properties, chemical descriptors and light harvesting studies of a new bioactive azo imidazole compound

VS Kumar, YS Mary, K Pradhan, D Brahman… - Journal of Molecular …, 2020 - Elsevier
The manuscript presents the synthesis and detailed spectral calculations of a new
azoimidazole compound 1-[2-(2-hydroxy-3-methoxy-5-phenylazobenzaldeneamino) ethyl]-3 …

Design and synthesis of three Fe (III) mixed-ligand complexes: Exploration of their biological and phenoxazinone synthase-like activities

M Ismael, AMM Abdel-Mawgoud, MK Rabia… - Inorganica Chimica …, 2020 - Elsevier
New Fe (III) complexes with mixed ligands based on 1-{(E)-[(4-methylphenyl) imino] methyl}-
2-naphthol (HN) as primary ligand and secondary co-ligand of O-hydroxy quinolone (HQ), 2 …

Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors

Y Li, C Tan, C Gao, C Zhang, X Luan, X Chen… - Bioorganic & medicinal …, 2011 - Elsevier
Multi-target EGFR, VEGFR-2 and PDGFR inhibitors are highly useful anticancer agents with
improved therapeutic efficacies. In this work, we used two virtual screening methods, support …

Screening of the Pandemic Response Box identifies anti-microsporidia compounds

Q Huang, J Chen, G Pan… - PLoS Neglected Tropical …, 2023 - journals.plos.org
Microsporidia are fungal obligate intracellular pathogens, which infect most animals and
cause microsporidiosis. Despite the serious threat that microsporidia pose to humans and …

Current therapy and therapeutic targets for microsporidiosis

J Wei, Z Fei, G Pan, LM Weiss, Z Zhou - Frontiers in Microbiology, 2022 - frontiersin.org
Microsporidia are obligate intracellular, spore-forming parasitic fungi which are grouped with
the Cryptomycota. They are both opportunistic pathogens in humans and emerging …