Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …

Aerobic glycolysis is the process of oxidation of glucose into pyruvate followed by lactate
production under normoxic condition. Distinctive from its anaerobic counterpart (ie glycolysis …

Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer
(CRC) development. However, the underlying mechanisms have yet to be elucidated. B7 …

Newcastle disease virus (NDV) can modulate cancer cell signaling pathway and induce
apoptosis in cancer cells. Cancer cells increase their glycolysis rates to meet the energy …

Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

Background Metabolic reprogramming, immune evasion and tumor-promoting inflammation
are three hallmarks of cancer that provide new perspectives for understanding the biology of …

Immunotherapies have significantly improved the survival of patients in many cancers over
the last decade. However, primary and secondary resistances are encountered in most …

Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells
are two fundamental mediators of tumor progression, including hepatocellular carcinoma …

Colon cancer is an aggressive malignancy with very limited therapeutic approaches. The
available therapeutic agents for colon cancer show strong adverse effects and poor …